Pharmacodynamics and Pharmacokinetics of Baycox® in Piglets

After oral administration to piglets, toltrazuril (Baycox) is absorbed slowly by the gut, as indicated in a radioactive study using [triazine-2-14C]-marked toltrazuril.

This is followed by long-lasting distribution among the different compartments of the body. The plasma half-life is 51 hours. Excretion is characterised by a high faecal fraction with a relatively high excretion rate.

There is no significant enterohepatic circulation. Two metabolites of toltrazuril, both oxidation products, toltrazuril-sulfoxide and toltrazuril-sulfone, are found in the tissues and organs of piglets.